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But if you do not have enough time or do not feel up to the complexity of the software, a feature-rich Open Source alternative is made available. Bforartists is an open-source 2D and 3D software that doesn’t require a programming background to master it. It is quite easy to use and gives the user an incredible artistic freedom. You can import various 2D and 3D images and manipulate them to produce professional results. That’s why Bforartists is also a great choice for visual designers, artists, and even for photographers. Preview: Version: Blender 2.73c Examplestreams: Default Name: Thank you very much @bartmann for creating the torrent! Unregulated, off-label use of drugs in infants and children: are the results of a systematic review and meta-analysis valid? To evaluate the incidence of off-label use of drugs in infants and children. Systematic review and meta-analysis. A systematic search of the PubMed, Cinahl, Cochrane Library, Psychinfo, Scielo, and Embase databases was performed to identify studies addressing off-label use of drugs in children between 2003 and 2008. Quality of the studies was assessed using the STROBE guideline and the Cochrane Collaboration tool. A systematic review was conducted on the incidence of off-label use of drugs in infants and children. In addition, a random-effects meta-analysis was performed. One hundred forty-one studies were identified and included in the systematic review. Two studies reported clinical trials, 95 reports addressed off-label use of drugs in infants, and 44 reported studies the use of drugs in children. A total of 5,664 cases of off-label use of drugs were identified and reviewed. The meta-analysis revealed that the rate of off-label use of drugs in infants was 11.24% (95% confidence interval [95% CI] 9.35-13.12%) and in children it was 0.72% (95% CI 0.46-1.02%). 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